Nancy Mace wins South Carolina 1st congressional district primary over Kevin McCarthy-backed challenger

For a second straight election, Republican Rep. Nancy Mace of South Carolina has survived a serious primary challenge. 

The Associated Press on Tuesday projects that Mace will win renomination in South Carolina's competitive Low Country-based 1st Congressional District by defeating Catherine Templeton, a former director of South Carolina's labor agency who ran unsuccessfully for governor in 2018, and Marine Corps veteran Bill Young.

Templeton was backed by millions spent by outside groups aligned with former House Speaker Kevin McCarthy.

Mace, who was first elected to the House in 2020, survived a primary challenge against a former President Trump-backed Republican two years ago. The former president had targeted Mace after she blamed him for the Jan. 6, 2021 attack on the U.S. Capitol by Trump supporters aiming to upend congressional certification of President Biden's 2020 election victory.

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Fast-forward two years, and Mace now has Trump's backing after she endorsed the former president and campaigned for him earlier this year in South Carolina's crucial GOP presidential primary.

However, unlike two years ago, when then-Speaker McCarthy had her back, the now-former House speaker targeted Mace, who last year was one of eight House Republicans to break ranks and vote to oust McCarthy. The former speaker is seeking revenge as he works to defeat the eight Republican lawmakers.

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Around $9 million was shelled out to run ads in the primary, according to the national ad tracking firm AdImapct. Nearly half of the money came from McCarthy aligned outside groups that targeted Mace.

Mace, who was also backed by Republican Gov. Henry McMaster and current House Speaker Mike Johnson, had roughly $3 million in outside spending on her behalf.

Templeton was supported by former House Speaker Newt Gingrich and Rep. Joe Wilson of the neighboring 2nd Congressional District.

Mace has faced controversy as several of her congressional staffers quit late last year and earlier this year. Additionally, a former Mace chief of staff briefly launched a primary challenge against his former boss.

If none of the three candidates in the GOP primary had won a majority in Tuesday's contest, the top two contenders would have faced off in a runoff in two weeks.

Businessman Michael B. Moore and veteran Mac Deford were vying for the Democrat nod in the 1st District.

Get the latest updates from the 2024 campaign trail, exclusive interviews and more at our Fox News Digital election hub.

Experimental Alzheimer’s drug gets FDA advisory panel's thumbs-up: ‘Progress is happening’

An experimental Alzheimer’s drug, donanemab, was endorsed by a U.S. Food and Drug Administration (FDA) advisory panel on Monday.

Donanemab is designed to treat symptoms of early Alzheimer’s disease, including mild cognitive impairment and mild Alzheimer’s dementia.

At the FDA's Peripheral and Central Nervous System Advisory Committee hearing, which was held in Maryland on Monday, the advisers unanimously agreed that the drug’s benefits outweigh any potential risks.

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While this isn’t a guarantee the FDA will approve the drug, the agency does typically follow the panel’s recommendations, per reports.

Officials at Eli Lilly, the Indiana pharmaceutical company that makes donanemab, were also in attendance, fielding questions from the committee about potential side effects.

At the Monday hearing, Eli Lilly officials presented clinical trial results that showed the drug slowed cognitive and functional decline for people with mild cognitive impairment due to early stages of Alzheimer’s.

The study was also published by the Journal of the American Medical Association.

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In phase 3 trials published in May 2023, donanemab was shown to "significantly slow cognitive and functional decline in people with early symptomatic Alzheimer's disease," according to a press release on Eli Lilly’s website.

If donanemab is approved, it would become only the second available medication designed to slow the progression of Alzheimer’s symptoms.

Leqembi, the first new Alzheimer’s treatment in 20 years, was given full FDA approval in July 2023.

Donanemab works by clearing built-up amyloid from the brain. It was shown to cause side effects such as "brain swelling and tiny bleeds," researchers found.

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The Alzheimer’s Association, based in Chicago, released a statement welcoming the FDA’s finding that donanemab is effective for the treatment of early Alzheimer’s disease.

"A future with more approved Alzheimer’s treatments is a tremendous advancement for people eligible for these drugs," said Joanne Pike, DrPH, Alzheimer’s Association president and CEO, in a statement provided to Fox News Digital. 

"Progress with treatment is happening. Now we need more types of treatments, targeting a variety of aspects of the disease, with greater efficacy and safety," she continued.

"A rich and robust life without the threat of memory loss, confusion or cognitive decline — this is what we envision."

The next step toward approval of donanemab is FDA review.

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, who was not involved in the drug trials, noted that donanemab is very similar to Leqembi, the current drug on the market that blocks amyloid formation. 

"The problem with … denonemab is similar — it can cause brain swelling and bleeding," Siegel told Fox News Digital.

"It is also expensive, as it’s once a month versus once every two weeks for Leqembi." 

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Denonemab is "somewhat more effective," Siegel noted, as it slows progression of Alzheimer’s by about 35% versus 27% for Leqembi.

"It may be better at removing plaques," he said.

There may be limitations associated with these types of drugs, however, according to the doctor.

"Many experts have told me that the obsession with amyloid formation may not be the holy grail it was once thought to be," Siegel told Fox News Digital. 

"The study didn't pay enough attention to tau proteins, which are also a key player here." 

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Tau proteins, which cause "tangles" in the brain of Alzheimer’s patients, are not the primary targets of these drugs, Siegel said. 

"There is also the issue of neuroinflammation and neuronal transmission abnormalities, which precede the buildup of the plaque proteins and are important targets for research."              

Fox News Digital reached out to Eli Lilly and the FDA requesting comment.

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