John Stamos defended his "Full House" co-star Lori Loughlin for putting up "with a lot over the years" during her relationship with estranged husband Mossimo Giannulli.

Loughlin and Giannulli are "living apart" now after 27 years of marriage, representatives confirmed to Fox News Digital. "There are no legal proceedings underway."

During Monday's episode of the "Good Guys" podcast, Stamos claimed it was the fashion designer who was responsible for getting Loughlin caught up in the 2019 college admissions scandal. 

LORI LOUGHLIN SPLITS FROM FASHION DESIGNER HUSBAND FIVE YEARS AFTER COLLEGE ADMISSIONS SCANDAL

Their separation came five years after the couple were entangled in the Operation Varsity Blues scandal, pleading guilty to wire and mail fraud related to paying hundreds of thousands in bribes to get their daughters into the University of Southern California.

"40 years I’ve known her," Stamos said. "You can see through people after a few years. This woman’s a saint. I’m just heartbroken for her right now."

LORI LOUGHLIN PRAISES LAW ENFORCEMENT 5 YEARS AFTER COLLEGE ADMISSIONS SCANDAL 

Stamos "really tried to be there" for his former co-star during the scandal, and claimed that Giannulli was "a terrible narcissist."

"I’m not going to debate whether she had much to do with it or not. I know she didn’t," he said before claiming Giannulli "dragged her through that."

"She’s not a liar. She’s a saint," Stamos said before remembering he called to check on Loughlin when the scandal news broke. She allegedly told him that "Mossimo handles all that stuff."

Loughlin served nearly three months in prison and Giannulli served five months behind bars. They were released in December 2020 and April 2021. 

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"She goes to f--ing prison for this a--hole for three months, right? And he goes for whatever," Stamos said. "And in typical Lori fashion, I said, ‘How was it?’ She goes, ‘You know, I met a lot of nice ladies in there. We have a book club.'"

He continued, "She didn’t deserve to be dragged through that … I know for a fact it was all him."

Stamos admitted that Loughlin was "just devastated" to split up with her husband of 27 years. 

"For a girl who, you know, has lived her life really well, [is] a good person, a good mother, a good wife," he said. "I know all this for a fact. To be thrown into, now, this separation and exploding, blowing up her family this way. And I just hate to see her go through this."

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When asked about cheating allegations, Stamos was "taking a fifth," but noted, "Whatever he did to her, it busted her up to the core."

Loughlin recently made light of the scandal when she played a version of herself in an episode of "Curb Your Enthusiasm." In the episode, main character Larry David helps the actress get into a country club when she’s bogged down with her legal drama. 

Her character also has a fake handicapped license plate and cheats at golf. 

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In an interview with First for Women last year, Loughlin talked about perseverance. 

"Every day, we’re met with different obstacles. But, for me, it’s like that song says, ‘I get knocked down, but I get up again,’" she said. "Nobody said life was going to be a breeze; we all make mistakes, but the important thing is to persevere."

While President Donald Trump and his administration brushed off the "No Kings" nationwide protests rebuking the president over the weekend, Democrats lauded the protesters for standing up for democracy. 

The protest marked at least the second time "No Kings" rallies have been organized across the country in major cities, including Washington, New York City and Los Angeles, since Trump took office for the second time, and organizers claim the protests are in opposition to his authoritarian policies. 

Meanwhile, Trump pushed back on the description of "king," as he and other Republicans poked fun at the millions participating in the rallies. 

PROTESTERS NATIONWIDE HOLD 'NO KINGS' RALLIES AMID GOVERNMENT SHUTDOWN

"I’m not a king," Trump told reporters Sunday on Air Force One. "I work my ass off to make our country great. That’s all it is. I’m not a king at all."

Trump also characterized the protests as inconsequential, and said that those who participated didn’t accurately reflect the people who make up the U.S. 

"The demonstrations were very small, very ineffective and the people were whacked out," Trump said Sunday. "When you look at those people, those are not representative of the people of our country."

Despite Trump’s rejection of being labeled a king, the official White House social media accounts previously posted an image in February of Trump wearing a crown with a caption claiming "long live the king." Trump also reposted an AI-generated video that Vice President JD Vance originally shared, depicting Trump placing a crown on his head and drawing a sword. 

Additionally, Trump shared another AI-generated video of him donning a crown in a fighter jet over New York City, unloading what appeared to be feces on the protesters. 

WATCH: 'NO KINGS' PROTESTERS AT MASSIVE NYC RALLY REVEAL MOTIVATION FOR TAKING TO THE STREETS: 'DISGUSTING'

Meanwhile, Speaker of the House Mike Johnson, R-La., said that Senate Minority Leader Chuck Schumer, D-N.Y. needed a distraction from the government shutdown that started Oct. 1, although Johnson did admit that the protests turned out to be a "violent-free, free speech exercise." 

"They needed a stunt," Johnson said in an interview with ABC Sunday. "They needed a show. Chuck Schumer has — needs cover right now. He’s closed the government down because he needs political cover, and this was a part of it."

However, Democrats said the protests were an opportunity to stand up for democracy. For example, Schumer said that there a "no dictators" in the U.S., and that "we won’t allow Trump to keep eroding our democracy." 

"Dictators evolve when good people of all different beliefs and backgrounds stay silent," Schumer said in a social media post on Saturday. "This No Kings Day says we will not stay silent.

Additionally, former Speaker of the House Nancy Pelosi shared a video clip of her dismantling a plastic crown, appearing to harken back to when she ripped Trump’s State of the Union address in 2020. 

"We’re gonna tear up the crown!" Pelosi said in the brief clip, which she shared on social media with the caption: "No crown. #NoKings!" 

NATIONWIDE UNREST LOOMS AS ‘NO KINGS’ DEMONSTRATORS BEGIN TO GATHER IN MAJOR US CITIES

Sen. Adam Schiff, D-Calif., also weighed in, claiming "we said ‘hell no’ to kings, and reminded the nation and the world what patriotism looks like." 

"From our nation's capitol to cities across California, millions stood shoulder to shoulder to say that our democracy is worth fighting for, that our voices will not be silent, and that we will not sit back and let a wannabe king take our freedoms," Schiff said Saturday to accompany several photos of himself at the protest in Washington. "Proud to stand with you." 

Additionally, Sen. Patty Murray, D-Wash., said the protests were reflective of the democratic process in the U.S. 

"This is what democracy looks like!" Murray said in a Saturday social media post. "We use our voices and our votes. NO KINGS IN AMERICA!"