The Colorado Buffaloes will be playing the rest of their game Saturday night without one of the head coach's sons.

Shilo Sanders was ejected in the second quarter after a targeting penalty.

The safety, the older brother of quarterback Shedeur Sanders, tackled Carsen Ryan of UCLA after he made a 3-yard reception with 3:20 to go in the second. 

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The crown of his helmet looked to make contact with the UCLA player's helmet, and it appeared Sanders left his feet to make the hit.

The NCAA defines targeting as "forcible contact to the head or neck area of a defenseless opponent with the helmet, forearm, hand, fist, elbow or shoulder."

Sanders was immediately flagged for the hit, and he flexed after making the tackle.

Earlier in the quarter, Sanders forced a fumble the Buffaloes recovered.

Sanders began his college career at South Carolina before transferring to Jackson State to play with his brother and for his father. The three moved on to Colorado in the offseason.

The Buffs won their first three games of the season, but they've lost three of their last four. They won a single game last season. 

CALIFORNIA-USC GAME DELAYED AFTER STUDENTS PROTEST PROFESSOR'S STALKING SUSPENSION

After their three-game winning streak, they got blown out by Oregon. They almost came back against USC, which was ranked No. 8, and defeated Arizona State on a walk-off field goal before falling to Stanford in overtime two weeks ago.

Shilo Sanders wears No. 21, the same number his father wore during his Hall of Fame career.

Entering Saturday, the safety had 36 tackles, 30 of them solo, a forced fumble and an interception.

Clemson entered its game against N.C. State Saturday as a 9.5-point favorite, so it wasn't necessarily crazy for former NFL wide receiver Steve Smith Sr. to predict the Tigers would come away with a win.

However, Smith made a rather bold statement about the game on ESPN's "College GameDay," slighting the Wolfpack and calling N.C. State a basketball school.

"Clemson has been struggling. They're not the Clemson that we've loved over the years. But N.C. State, unfortunately, they're waiting for basketball to start," Smith said.

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Smith wound up eating his words after N.C. State pulled off an upset with a 24-17 win.

It became apparent right after the game N.C. State head coach Dave Doeren heard what the former Carolina Panther had said.

"Tell Steve Smith in the studio this ain't a basketball school," Doeren said. "He can kiss my a--."

Doeren doubled down in his postgame press conference.

CALIFORNIA-USC GAME DELAYED AFTER STUDENTS PROTEST PROFESSOR'S STALKING SUSPENSION

"For a guy who lives in Charlotte, he clearly has got his head faced west all the time. No disrespect to him, but he disrespected our program, and I'm not gonna let people do that. These kids have worked their butt off. We've won a lot of football games here. … He can take that and put it where it belongs," Doeren said.

"This is not a basketball school. This is a great, great school that has great sports, and football's one of them. He wants to come see me, we can talk about that. But do your homework before you start talking s---."

Smith isn't afraid to speak his mind on the air. Before a recent Denver Broncos game, he said he would advise general managers not to trade for wide receiver Jerry Jeudy because he is "mentally unable to handle constructive criticism."

The Wolfpack host Miami next weekend.