Marvel is back on top with "Deadpool & Wolverine." The comic-book movie made a staggering $205 million in its first weekend in North American theaters, according to studio estimates Sunday. It shattered the opening record for R-rated films previously held by the first "Deadpool" ($132 million) and notched a spot in the top 10 openings of all time.

Including international showings, where it’s racked up an additional $233.3 million from 52 markets, "Deadpool & Wolverine" is looking at a global opening of over $438.3 million.

Fittingly for both characters’ introduction to the Marvel Cinematic Universe, "Deadpool & Wolverine" played less like earlier X-Men or Deadpool movies and more like an Avengers pic. In the top domestic opening weekends ever, "Deadpool & Wolverine" is seated in 8th place between "The Avengers" ($207.4 million) and "Black Panther" ($202 million), bumping "Avengers: Age of Ultron" ($191.3 million) out of the top 10.

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It’s by far biggest opening of the year, unseating Disney’s "Inside Out 2" ($154.2 million) and the most tickets a movie has sold in its debut weekend since "Barbie" ($162 million) stormed theaters last July. Playing in 4,210 locations, "Deadpool & Wolverine" also surpassed 2019’s "The Lion King" ($191.8 million) to become the biggest July opening ever, and is the 34th consecutive MCU movie to debut in first place. And these are numbers previously thought impossible for an R-rated film.

"It’s great news full stop," said Tony Chambers, who leads theatrical distribution for Disney. "Not only is it great for Disney, not only is it great for Marvel, but it’s great for the industry as a whole. We’ve said it before but success begets success."

That the numbers came alongside an R-rating, Chambers added, was "nothing short of phenomenal."

The Walt Disney Studios release arrived at a pivotal time for an industry grappling with box office returns that continue to run at a double-digit deficit from last year. Disney has played a vital role in the summer season, releasing the top movies in May ("Kingdom of the Planet of the Apes"), June ("Inside Out 2″) and now July.

The success is also an important moment for Marvel Studios, which has had several high-profile disappointments lately; Most notably in "The Marvels" which opened to an MCU low of $47 million last November.

Superheroes have been struggling even more elsewhere: Sony, which reached a high point with "Spider-Man: No Way Home" ($1.9 billion worldwide) had a new low with "Madame Web," which barely crossed $100 million. Warner Bros. Discovery, after a string of disappointments with "The Flash" and "Blue Beetle," is currently working on restarting their DC universe under the supervision of James Gunn.

Marvel's savior came in the form of two characters who got their start outside of the MCU. Both Deadpool and Wolverine, played by Ryan Reynolds and Hugh Jackman, existed previously under the 21st Century Fox banner which for two decades had the rights to Marvel characters like the "X-Men" and "Fantastic Four." That changed when Disney acquired the studio’s film and TV assets in early 2019 and plans started to take shape of how all these characters would fit into Kevin Feige’s MCU. In some cases, as with "Fantastic Four," Marvel Studios is starting fresh. With "Deadpool & Wolverine," directed by Shawn Levy, the stars were as crucial as their characters.

This weekend at the Comic-Con fan convention, Marvel also teased more to come, including Robert Downey Jr.’s return — not as Iron Man but as Doctor Doom.

Going into the weekend, $200 million domestic seemed like a pipe dream. Analysts were more conservative with predictions in the $160 million range. But from the start of the 3 p.m. Thursday preview screenings it was clear that "Deadpool & Wolverine" was more powerful. By the end of Friday, it had already made $96 million and received a coveted A CinemaScore from audiences. Critics, too, have been mostly positive. Premium screens, including IMAX and other large formats, accounted for 18% of the total box office.

"Historically, PG-13 is the rating that will get you the biggest bang for your buck," said Paul Dergarabedian, the senior media analyst for Comscore.

"The old rule that R-rated movies have a box office ceiling was literally shattered this weekend. The edgier content actually enhances their appeal to older teens and young 20-somethings."

The top domestic opening of all time still firmly belongs to "Avengers: Endgame" with $357.1 million. It’s followed by "Spider-Man: No Way Home" ($260.1 million), "Avengers: Infinity War" ($257.6 million), "Star Wars: The Force Awakens" ($247.9 million) and "Star Wars: The Last Jedi" ($220 million).

Second place went to Universal's "Twisters," now in its second weekend with $35.3 million. The standalone sequel to "Twister" has now earned $154.9 million in North America. Universal also claimed third place with "Despicable Me 4," which added $14.2 million in its fourth weekend, bringing its domestic total to nearly $291 million.

"Inside Out 2" landed in fourth place with $8.3 million. The Disney and Pixar release this week became the biggest animated release ever with $613.4 million domestically (surpassing "Incredibles 2") and $1.5 billion globally. It also passed "Top Gun: Maverick" to become the 12th highest-earning global release of all time.

It all adds up to one of the top 10 domestic grossing weekends of all time, with $277.5 million, according to Comscore. That puts it ahead of this weekend last year, when "Barbie" and "Oppenheimer" helped propel the box office to over $216.9 million in their second weekends.

"This is one for the history books," Dergarabedian said. "Hopefully this will carry over into August."

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Comscore. Final domestic figures will be released Monday.

Sen. JD Vance fired back at Democrats for their latest attack on his recently revived quip about "childless cat ladies" running the country, accusing them of taking the remark out of context. 

"If you look at the full context of what I said, it's very clear the Democrats have tried to take this thing out of context and blow it out of proportion, which is what they always do because they don't have an agenda to run on themselves," he told Fox News' Trey Gowdy on "Sunday Night in America."

In the 2021 interview in focus, Vance said, "We are effectively run in this country, via the Democrats, via our corporate oligarchs, by a bunch of childless cat ladies who are miserable at their own lives and the choices that they’ve made, and so they wanna make the rest of the country miserable, too."

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He also specifically called out prominent left-wing figures, including Vice President Kamala Harris and Rep. Alexandria Ocasio-Cortez, D-N.Y., as examples of that type.

After the comment resurfaced, the Ohio senator and Trump running mate took heat from the likes of former Secretary of State Hillary Clinton, actress Jennifer Aniston, and the Harris campaign for allegedly devaluing women who do not have children or are unable to have children.

He clarified his intent on Sunday.

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"If you look at what the American people are most concerned about, it's not an out-of-context quip I made three years ago. It's the fact that Kamala Harris, the border czar, opened the American southern border. It's the fact that the Democratic Party has become explicitly anti-family in some of their policies," he said.

"In fact, you just heard Kamala Harris in a surfaced clip recently talk about how it was a bad idea to have kids because of climate change anxiety, so what I'm trying to get at here is that it's important for us to be pro-family as a country. Of course, for a whole host of reasons, it's not going to work out for some people. We should pray for those people and have sympathy for them. I still think that means we should be pro-family, generally speaking, as a party," he added.

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Vance said he believes that being a parent has a "profound" effect on one's perspective, and slammed Democrats again for allegedly touting anti-child and anti-family rhetoric.

"There are a whole host of people who don't have children for a whole host of reasons, and they certainly are great people who can participate fully in the life of this country," he said, adding shortly after, "So this is not a criticism and was never a criticism of everybody without children. That is a lie of the left. It is a criticism of the increasingly anti-parents and anti-child attitude of the left."

Fox News' Gabriel Hays contributed to this report.