Four people were killed and at least 21 others were wounded in a mass shooting Saturday night in Birmingham, Alabama.

Two men and a woman were killed at the scene in the 2000 block of Magnolia Avenue in the Five Points South area near the University of Alabama at Birmingham, while a fourth victim died at the university's hospital, Birmingham Police told AL.com.

The incident happened shortly after 11 p.m., Officer Truman Fitzgerald told the outlet.

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Birmingham Fire and Rescue transported eight victims to the hospital, and police said four of those victims sustained life-threatening wounds.

Many others also arrived at hospitals in private vehicles.

Police say multiple gunmen are believed to be responsible for the shooting. No suspects have been taken into custody.

"Rest assured, we are going to do everything we possibly can to uncover, identify and hunt down whoever was responsible for preying on our people," Fitzgerald told AL.com.

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Streets have been blocked off in the area as police continue to investigate.

Fitzgerald said police have reached out to the FBI and ATF for assistance.

Vice President Kamala Harris has gone 63 days as the presumptive, and now, official Democratic nominee for president without holding an official press conference. 

Under pressure to sit down for a substantive interview after weeks of stonewalling, Harris finally ended her interview drought last month in Georgia when she was joined by running mate Tim Walz for a pre-taped piece with CNN's Dana Bash that was a far cry from a traditional press conference. She's done more interviews since, including this week with the National Association of Black Journalists, and she made time to hang out with supporter Oprah Winfrey on Thursday at a star-studded campaign event.

Trump held his third news conference since the beginning of August earlier this month in California, taking the opportunity to roast his opponent's home state and hold forth on a number of topics, including crime, immigration and inflation.

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Harris has stepped up her interviews in recent weeks, including doing radio hits and a solo sit-down with a Philadelphia TV station last week.

But as for when she'll actually do a formal press conference as a candidate, that day may never come, at least while she's still a candidate.

Conservative Radio Libre host Jorge Bonilla feels Harris should do a press conference but said it’s almost "irrelevant" because she continues to get a pass. 

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"She is highly unlikely to do a press conference because the media have enabled and encouraged her ‘plexiglass basement’ strategy, wherein she preserves the illusion of being out there while remaining wholly inaccessible to the press and therefore unaccountable," Bonilla told Fox News Digital.

Trump has sought to highlight the contrast in media availability between the two, sitting for several lengthy interviews in recent weeks, in addition to his three news conferences.

In her interview on Friday in Philadelphia, her answer citing her middle-class upbringing when asked about specifics of her economic policy drew sharp criticism.

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"You know, I grew up in a neighborhood of folks who were very proud of their lawn," she said. "And I was raised to believe and to know that all people deserve dignity, and that we as Americans have a beautiful character. You know, we have ambitions and aspirations and dreams, but not everyone necessarily has access to the resources that can help them fuel those dreams and ambitions. 

"So when I talk about building an opportunity economy, it is very much with the mind of investing in the ambitions and aspirations and the incredible work ethic of the American people and creating opportunity for people, for example, to start a small business."

Fox News Digital’s Paul Steinhauser contributed to this report.