The U.S. Food and Drug Administration (FDA) approved a new, twice-yearly shot — the first and only of its kind — to prevent HIV, the creator of the drug, Gilead Sciences, announced on Wednesday.

Sold under the name Yeztugo, the company’s injectable HIV-1 capsid inhibitor (lenacapavir) reduces the risk of sexually acquired HIV in adults and adolescents.

"This is a historic day in the decades-long fight against HIV," said Daniel O’Day, chairman and CEO of California-based Gilead Sciences, in a press release.

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The medicine, which only needs to be administered twice a year, has shown "remarkable outcomes in clinical studies," as Gilead claims it could transform HIV prevention.

The drug is given as an injectable under the skin that the body then slowly absorbs. Individuals must have a negative HIV-1 test prior to starting the treatment.

In large trials last year, the drug was not only nearly 100% effective in its prevention of HIV, but proved superior to once-daily oral medication like Truvada, another drug by Gilead.

The journal Science named lenacapavir its 2024 "Breakthrough of the Year."

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Lenacapavir uses a multi-stage approach that distinguishes it from other approved antiviral medications. 

"While most antivirals act on just one stage of viral replication, lenacapavir is designed to inhibit HIV at multiple stages of its lifecycle," states the press release from Gilead.

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"Yeztugo is one of the most important scientific breakthroughs of our time and offers a very real opportunity to help end the HIV epidemic," O’Day said in the press release.

The most commonly reported adverse reactions during clinical trials included injection site reactions, headache and nausea, according to the company.

Caitlin Clark spent part of her offseason on the golf course, teaming up with Nelly Korda and Annika Sorenstam in a pro-am at Pelican Golf Club in November.

The Indiana Fever star played the front nine with Korda and the back nine with Sorenstam. Clark had joked after the team was eliminated from the playoffs that she would take up golfing – and likely did not expect to hit the course with a legend like Sorenstam.

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In a recent interview with Fox News Digital, Sorenstam recalled playing with Clark on the golf course and said she was a "bigger fan" after meeting the young basketball player.

"It’s great, obviously, I’m a big fan, and bigger fan after meeting her and spending some time, great athlete very focused, understands when you have a task to do it," she said. "Obviously she has a little golf background, so she is familiar with the sport and understands it to have the culture and have the tradition a little bit.

"No, it is great to bring new people to the sport, get excited and for us to walk around and share stories. To be anything from, I was in college, I was a professional, how to do this or that, working out, there is a lot of things we have in common. It is always fun to listen to other successful athletes or people to pick their brands. Just felt like she was very mature and down to earth in a way."

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Clark said at a leadership summit connected with the pro-am in November that she tries to practice as much as she can.

"I’ve tried to take as much time as I can to practice, but there is only so much hope. You just cross your fingers, pray," she said at the time. "No, I’ve practiced a little bit and I just had the quote about becoming a professional golfer. Everybody thought I was serious. I was not serious. I love it. I love being outside and making it competitive with my friends.

"It’s challenging and getting to come here and be around the best and have a good time is what I’m looking forward to."

Sorenstam is getting ready to participate in the American Century Championship, which takes place at Edgewood Tahoe Golf Club next month. The festivities start on July 9 and run through July 13.

The Associated Press contributed to this report.

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