President Donald Trump’s “one big, beautiful bill” hit a major roadblock in Congress on Friday as GOP infighting stalled progress.

The House Budget Committee failed to advance its portion of the bill in a 16-21 vote, with five Republicans joining Democrats over a dispute on the degree and timing of efforts to rein in the deficit, benefits, and environmental programs.

The outcome is a blow to House GOP leadership, which hopes to get the overall bill passed by Memorial Day. Budget Chairman Jodey Arrington (R-TX) said he did not expect the panel to meet again on Friday and suggested it could take another crack at the legislation on Monday.

With negotiations likely to stretch into the weekend, members will have to consider that certain alterations to placate the GOP holdouts might alienate other Republicans.

One of the GOP defectors, Rep. Lloyd Smucker (R-PA), explained on X that he “fully” supports the “one big, beautiful bill” and his vote was a “procedural requirement to preserve the committee’s opportunity to reconsider the motion to advance” it.

The other Republicans who opposed the legislation included conservative Reps. Chip Roy (R-TX), Andrew Clyde (R-GA), Josh Brecheen (R-OK), and Ralph Norman (R-SC). Doing more to shrink the deficit, benefit reform, and repealing the “Green New Scam” are among their priorities.

“Reps. Roy, Norman, Brecheen, Clyde and others continue to work in good faith to enact the President’s ‘Big Beautiful Bill’ — we were making progress before the vote in the Budget Committee and will continue negotiations to further improve the reconciliation package,” the House Freedom Caucus said in a post on X. “We are not going anywhere and we will continue to work through the weekend.”

Trump, who wrapped up a tour through the Middle East this week, had called on Republicans to pass the overall tax and budget bill to implement various priorities of his second term.

“Republicans MUST UNITE behind, ‘THE ONE, BIG BEAUTIFUL BILL!’ Not only does it cut Taxes for ALL Americans, but it will kick millions of Illegal Aliens off of Medicaid to PROTECT it for those who are the ones in real need,” Trump said in a post on Truth Social.

“The Country will suffer greatly without this Legislation, with their Taxes going up 65%,” he added. “It will be blamed on the Democrats, but that doesn’t help our Voters. We don’t need “GRANDSTANDERS” in the Republican Party. STOP TALKING, AND GET IT DONE! It is time to fix the MESS that Biden and the Democrats gave us. Thank you for your attention to this matter!”

Other House committees advanced their respective parts of the bill this week, but there are certain matters within those pieces that might need to change in order for a sufficient number of Republicans and their slim majority to rally around the final product, including the state and local tax (SALT) deduction cap.

Democrats who are focused on pushing back on Trump’s agenda celebrated the House Budget Committee snafu.

“BREAKING: We just stopped the Republican budget bill in committee,” Rep. Brandon Boyle (D-PA) said on X. “Whether it’s adding trillions to the debt, massive giveaways to billionaires, or millions of Americans kicked off their health care, Republicans know how unpopular this bill is. We won’t stop fighting back.”

If and when the “one big, beautiful bill” gets passed through the House, it will head to the Senate, which also has a narrow GOP majority. There, the measure could also have a difficult time as some Republicans have already voiced objections to its handling of Medicaid and spending cuts.

This week, every GOP senator except one and 177 out of 220 GOP members of the House signed a letter to President Donald Trump supporting his past statements and urging that Iran’s capacity to enrich uranium be permanently eliminated.

The effort was spearheaded by Nebraska Republican Sen. Pete Ricketts and House Republican Study Committee Chair Rep. August Pfluger (R-TX). Kentucky GOP Sen. Rand Paul was the only Republican senator who would not sign the letter.

The signatories acknowledged Trump’s “strong support” for “efforts to secure a deal with Iran that dismantles its nuclear program, and to reinforce the explicit warnings that you and officials in your administration have issued that the regime must permanently give up any capacity for enrichment.”

After noting Trump’s first-term withdrawal from the “deeply broken” Joint Comprehensive Plan of Action (JCPOA) and his imposition of maximum pressure on the regime, the signatories pointed out that the Obama JCPOA deal “allowed Iran to sell oil, provided waivers allowing third countries to help Iran build out its nuclear program, and included the termination of United Nations sanctions on the regime.”

They noted that Trump’s maximum pressure campaign had deterred Iran from making substantial nuclear progress. “Tragically, the Biden administration systematically undid that pressure, functionally re-implementing the nuclear deal. They immediately rescinded your decision to reimpose U.N. sanctions, allowed Iran to sell oil at JCPOA-levels, and even re-issued waivers allowing Iran to build out its nuclear program,” they continued.

“As you predicted, those policies indeed allowed Iran to reach the brink of nuclear breakout, which is where they are today,” they asserted. “The scope and breadth of Iran’s nuclear buildout have made it impossible to verify any new deal that allows Iran to continue enriching uranium. In its most recent report, published on February 26, the International Atomic Energy Agency confirmed that because of Iran’s activities over the last four years, ‘the Agency has lost continuity of knowledge in relation to the production and current inventory of centrifuges, rotors and bellows, heavy water and UOC, which it will not be possible to restore.’”

They quoted Trump’s National Security Presidential Memorandum that stated, “Iran’s nuclear program, including its enrichment- and reprocessing-related capabilities and nuclear-capable missiles, poses an existential danger to the United States and the entire civilized world,” then additionally quoted him saying recently that only “full dismantlement” of those capabilities would be acceptable.

“We cannot afford another agreement that enables Iran to play for time, as the JCPOA did. The Iranian regime should know that the administration has Congressional backing to ensure their ability to enrich uranium is permanently eliminated,” they concluded.